Dr D P Singh
Designation Scientist-B
Divsion Toxicology
Email singh[dot]dpratap[at]icmr[dot]gov[dot]in
Contact +91-9914372591

Academic Qualifications

  • Ph. D. in Pharmaceutical Sciences

Membership/Fellowhips

  • International Society of Neurochemistry (ISN)

  • Society for Neuroscience (SfN)

  • Life membership to All India Association for Advancing Research in Obesity (AIAARO): National association of the World Obesity Federation

  • European Behavioural Pharmacology Society (EBPS)

  • American Society of Neurochemistry (ASN)


Awards/Honors

  • Postdoctoral fellowship at Sahlgrenska University Hospital, University of Gothenburg, Sweden (Aug. 2017- Dec. 2017)

  • Senior Research Fellowship by National Agri-food Biotechnology Institute (NABI), Mohali (Sep. 2015 – Aug. 2017)

  • Junior Research Fellowship by National Agri-food Biotechnology Institute (NABI), Mohali (Sep. 2013 – Aug. 2015)

  • Post graduate fellowship by UGC (based on GPAT 2011- AIR 41) for Masters’ in Pharmacy in Pharmacology at Panjab University, Chandigarh (Aug. 2011 – July 2013)


Research Interest

  • Neurobehavioral Pharmacology and toxicology; Diabetes, Obesity and Metabolic disorders; Food & Nutritional Biochemistry; Host-Gut microbial interaction


Patent Application

  • Bishnoi M, Kondepudi KK, Chopra K, Singh DP, Khare P. A process for the development of a novel class of functional foods for better metabolic health and uses there of. Indian patent (Temp Num: TEMP/E-1/8162/2017-DEL).


Publications

  • Number of Publications : 16

  1. Dhaliwal J.*, Singh D.P.*, Singh S., Pinnaka A.K., Boparai R.K., Bishnoi M., Kondepudi K.K., Chopra K. Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation‐induced behaviour, biochemical and selected gut microbial aberrations in mice. J Appl Microbiol 2018; Accepted article doi: 10.1111/jam.13765 [Equal first author] (IF 2.099)


  2. Sarma S.M.*, Singh D.P.*, Singh P., Khare P., Mangal P., Singh S., Bijalwan V., Kaur J., Mantri S., Boparai R.K., Mazumder K., Bishnoi M., Bhutani K.K., Kondepudi K.K. Finger millet arabinoxylan protects mice from high-fat diet induced lipid derangements, inflammation, endotoxemia and gut bacterial dysbiosis. Int J Biological Macromol  2018;, 106: 994 – 1003. [Equal first author] (IF 3.671)


  3. Baboota R.K., Khare P., Mangal P., Singh D.P., Bhutani K.K., Kondepudi K.K., Kaur J., Bishnoi M. Dihydrocapsiate supplementation prevented high-fat diet–induced adiposity, hepatic steatosis, glucose intolerance, and gut morphological alterations in mice. Nutr Res 2018; 51: 40 – 56. (IF 2.737).


  4. Singh D.P., Singh S., Bijalwan V., Kumar V., Khare P., Baboota R.K., Singh P., Boparai R.K., Singh J., Kondepudi K.K., Chopra K., Bishnoi M. Co-supplementation of isomalto-oligosaccharides potentiates metabolic health benefits of polyphenol-rich cranberry extract in high fat diet-fed mice via enhanced gut butyrate production. Eur J Nutrition 2017. Accepted Manuscript doi:10.1007/s00394-017-1561-5. (IF 4.37) 


  5. Mittal R., Kumar A., Singh D.P., Bishnoi M., Nag T.C. Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway. Inflammopharmacology 2018; 26: 755 -768. (IF 2.59)


  6. Singh D.P., Singh J., Boparai R.K., Zhu J.H., Mantri S., Khare P., Khardori R., Kondepudi K.K., Chopra K., Bishnoi M. Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice. Pharmacol Res 2017; 123, 103 -113. (IF 4.48)


  7. Singh D.P., Khare P., Bijalwan V., Baboota R.K., Singh J., Kondepudi K.K., Chopra K., Bishnoi M. Co-administration of Isomalto-oligosaccharides augments metabolic health benefits of cinnamaldehyde in high fat diet fed mice. Biofactors 2017; 43: 831-835. (IF 3.23) 


  8. Deol P.K., Khare P., Singh D.P., Soman G., Bishnoi M., Kondepudi K.K., Kaur I.P. Managing colonic inflammation associated gut derangements by systematically optimised and targeted ginger extract–Lactobacillus acidophilus loaded pharmacobiotic alginate beads. Int J Biological Macromol 2017; 105: 81 – 91. (IF 3.67)


  9. Sarma S.M., Khare P., Jagtap S., Singh D.P., Baboota R.K., Podili K., Boparai R.K., Kaur J., Bhutani K.K., Bishnoi M., kondepudi K.K. Kodo millet whole grain and bran supplementation prevents high-fat diet induced derangements in a lipid profile, inflammatory status and gut bacteria in mice. Food Funct 2017; 8: 1174-1183. (IF 3.247)


  10. Singh D.P., Khare P., Zhu J., Kondepudi K.K., Singh J., Baboota R.K., Boparai R.K., Khardori R., Chopra K., Bishnoi M. A novel cobiotic-based preventive approach against high-fat diet-induced adiposity, nonalcoholic fatty liver and gut derangement in mice. Int J Obesity 2016; 40: 487-496. (IF 5.489, featured article March 2016 issue).


  11. Murtaza N., Baboota R.K., Jagtap S., Singh D.P., Khare P., Sarma S. M., Podili K., Alagesan S., Chandra T.S., Bhutani K.K., Boparai R.K., Bishnoi M., Kondepudi K.K. Finger millet bran supplementation alleviates obesity-induced oxidative stress, inflammation and gut microbial derangements in high-fat diet-fed mice. Br J Nutr 2014; 112: 1447 – 1458.(IF 3.706 )


  12. Baboota R.K., Murtaza N., Jagtap S., Singh D.P., Karmase A., Kaur J., Bhutani K.K., Boparai R.K., Premkumar L.S., Kondepudi K.K., Bishnoi M.. Capsaicin-induced transcriptional changes in hypothalamus and alterations in gut microbial count in high fat diet fed mice. J Nutr Biochem 2014; 25: 893-902. (IF 4.7)


  13. Baboota R.K., Singh D.P., Sarma S. M., Kaur J., Sandhir R., Boprai R. K., Kondepudi K.K., Bishnoi M. Capsaicin Induces ‘‘Brite’’ Phenotype in Differentiating 3T3-L1 Preadipocytes. PLoS ONE 2014; 9: e103093. (IF 3.6)


  14. Singh D.P., Chopra K. Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischemic stroke. Pharm Biochem Behav 2014; 120: 33-42.(IF 2.748)


  15. Singh D.P., Chopra K. Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia. Eur J Pharmacol 2013;720: 98-106. (IF 2.896)

Book Chapters

  1. Kondepudi K.K., Singh D.P., Podili K., Boparai R.K., Bishnoi M. Role of probiotics and prebiotics in the management of obesity. In: Khardori N. (Ed.), Food Microbiology in Human Health and Disease. Science Publishers (An Imprint of CRC Press/ Taylor & Francis Group. pp. 157 – 186. doi: 10.1201/b19874-10

Abstract Published in Different Journal Suppliments

  1. Singh D.P., Kondepudi K.K., Chopra K., Bishnoi M. Isomalto-oligosaccharides, lycopene and their combination (co-biotic) ameliorated high Fat diet-induced Gut derangements, metabolic endotoxemia, adiposity and Non-alcoholic fatty liver in mice. Obesity Reviews 2016; 17:163. Doi: 10.1111/obr.12403.

  2. Singh D., Chopra K. Neuroprotective effect of a combination of baicalin and catechin: evidences from rat model of transient global cerebral ischemia. J Neurochem 2015; 134: pp. 296. Doi: 10.1111/jnc.13189

  3. Bishnoi M., Singh D.P., Kondepudi K.K., Chopra K. Role of central and peripheral monoamine metabolism in obesity induced neuropsychiatric behavioural changes. Int J Neuropsychopharmacol 2014; 17 (suppl 1): 59. Doi: 10.1017/S1461145714000741.