Biochemistry

Objectives and Functions

  • Health risk assessment with special reference to occupational exposure and biochemical interaction
  • Studies of biomarkers of different occupational exposure with respect to public health interest
  • Molecular mechanism of tobacco-induced neurobehavioral signaling in brain-testis relation
  • Analysis of hormones, enzymes, apoptotic markers, degenerative markers etc. in different body fluids and tissues
  • Analysis of poison samples of referred poison cases (Poison Information Centre at Ahmedabad: WHO CC Activity)
  • Training and/or demonstration to Post graduate students of different academic organization about day-to-day laboratory techniques
  • Disseminate information in terms of research work publication.

Name Designation Email
Dr. Nibedita Naha Scientist-D & HoD naha[dot]n[at]gov[dot]in; niv_639[at]yahoo[dot]co[dot]in
Mr. Pradeep Upadhayay Technician 'C' upadhayay[dot]p[at]gov[dot]in
Mr.Himmatkumar N Makwana Technician 'C' makwana[dot]hn[at]icmr[dot]gov[dot]in
Mr. Ranjeet Kumar Technician 'A' kumar[dot]ra[at]icmr[dot]gov[dot]in
Mr.Shashwat Dodia MTS dodia[do]sl[at]gov[dot]in

On-going/Future Project

  • Evaluation of Indian reference value of Club cell protein as early biomarker in full blown silicosis and some silica dust exposed workers
  • Mechanism of action of Club cells in acute and chronic respiratory morbidity cases and validation of lead molecule in experimental model
  • Assessment of respiratory health in children residing in critically polluted areas using Club cell protein as biomarker- a feasibility study
  • Role of SIRT2 histone deacetylase in cadmium-induced renal toxicity in experimental model
  • WHO CC activity: retrospective study on the trend of poisoning in the city for last 3 years
  • Nrf2-BDNF-Dopaminergic signaling with respect to brain-testis relation in nicotine- and cigarette smoking-induced experimental models [DST-SERB, New Delhi sponsored]

Laboratory Facilities & Instruments

  • The laboratory personnel are skilled to carry out studies on experimental animals and humans, occupationally exposed to various toxicants as per the objectives and functions of the department
  • Providing laboratory reports for (1) serum and RBC cholinesterase levels as a poison information activity to various hospitals; and (2) serum Club cell protein levels as a dust-related respiratory morbidity marker to individual
  • The laboratory is equipped with tissue culture facility, biochemical analysis, neurobehavioral analysis of small rodent model, histology, immunohistochemistry and molecular biology related techniques

Project Completed

  • Club cell protein as an early biomarker of silicosis: a pilot study
  • Molecular mechanism of BDNF in adolescence brain of rodents with gestational nicotine exposure
  • BDNF-Dopaminergic local interaction in brain and testis of adult rodents with nicotine exposure
  • Health status of workers in ceramic industries and iron foundries in Gujarat. [DISH, Gujarat sponsored]
    [Please follow NIOH Annual Reports 2013 – 2017]

Last 05 Years Publications

  1. Naha N*, Gandhi DN, Gautam AK, Ravi Prakash J. Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex. Hum Expt Toxicol, 37(5): 540-556, 2018 (*Corresponding author, If: 1.8)

  2. Naha N*. Tobacco smoking and nicotine modulate Nrf2-BDNF-DA signaling in cerebral cortex and testis of adult rats during addiction and withdrawal. Biochem Anal Biochem, 7(S1):  35, 2018 (*Corresponding author, Invited paper in Cell Biologist Congress, Osaka; If: 2.63)

  3. Naha N*, Das M, Banerjee A. Toxic exposure and life style factors on ageing brain neurodegenerative disease, Alzheimer’s and Parkinson’s: role of natural antioxidants to ameliorate the condition. J Alcohol Drug Depend, 6( 2): 309-318,, 2018 (*Corresponding author, Invited Review; If: 1.57)

  4. Naha N*, Desai R, Fernandez JRD, Banerjee A. Globalization, obesity and polycystic ovary syndrome: What we pay? Austin Endocrin Diab Case Rep, 2(1): 1010-1018, 2017 (Peer reviewed journal; *Corresponding author: Invited Review for Special issue on Climate change & embryo loss: A global challenge)

  5. Muhamed J, Rajan A, Surendran A, Jaleel A, Anilkumar TV. Comparative profiling of extractable proteins in extracellular matrices of porcine cholecyst and jejunum intended for preparation of tissue engineering scaffolds. J Biomed Mater Res Part B: Appl Biomater, 105 (3): 489-96, 2017 (If: 3.37).

  6. Jain A, Ravi V, Muhamed J, Chatterjee K, Sundaresan NR. A simplified protocol for culture of murine neonatal cardiomyocytes on nanoscale keratin coated surfaces. Int J Cardiol 232: 160-70, 2017 (If: 6.19).

  7. Naha N*, Gandhi DN, Gautam AK, Patel S. Involvement of neurotransmitter and Nrf2 in nicotine- and cigarette smoke-induced testicular toxicity in adult rat. Reprod Biol Insight, 9: 5-17, 2016 (Peer reviewed journal; *Corresponding author)

  8. Majumder J, Bagepally BS, Shah P, Kotadiya S, Yadav S, Naha N. Comparison of workers’ perception towards work climate and health symptoms between ceramic and iron foundry workers. Ind J Occup Environ Health, 20: 48-53, 2016 (Peer reviewed journal; PubMed citation

  9. Naha N*. Lead and male reproduction: Impact of workplace exposure. ISSRF News Lett, 18 (1): 54-61, 2016. (Invited Review; *Corresponding author)

  10. Muhamed J, Revi D, Rajan A, Anilkumar TV. Comparative local immunogenic potential of scaffolds prepared from porcine cholecyst, jejunum, and urinary bladder in rat subcutaneous model. J Biomed Mater Res Part B: Appl Biomater, 103 (6): 1302-11, 2015 (If: 3.37).

  11. Naha N, Kumar S. Impact of lifestyle factors on deterioration of reproductive health in human. ISSRF News Lett, 14 (1): 6-11, 2014. (Review)

  12. Revi D, Vineetha VP, Muhamed J, Surendran GC, Rajan A, Kumary TV, et al. Wound healing potential of scaffolds prepared from porcine jejunum and urinary bladder by a non-detergent/enzymatic method. J Biomat Appl, 29 (9): 1218-29, 2014 (If: 2.08).

  13. Muhamed J, Revi D, Rajan A, Geetha S, Anilkumar TV. Biocompatibility and immunophenotypic characterization of a porcine cholecyst–derived scaffold implanted in rats. Toxicol Pathol, 43 (4): 536-45, 2014 (If: 1.97).

  14. Anilkumar TV, Vineetha VP, Revi D, Muhamed J, Rajan A. Biomaterial properties of cholecyst-derived scaffold recovered by a non-detergent/enzymatic method. J Biomed Mater Res Part B: Appl Biomater, 102 (7): 1506-16, 2014 (If: 3.37).

National and International conferences / Symposium

  1. Cell Biologists Congress (2018) organized by Cell and Structural Biology Conference Series LLC, USA at Osaka, Japan. Invited Speaker

  2. International Conference on Reproductive Biology and Comparative Endocrinology (2018) organized by SRBCE and BITS-Pilani, Goa. Invited Speaker

  3. International Conference on Reproductive Biology and Comparative Endocrinology (2017) organized by SRBCE and University of Hyderabad, Hyderabad. Invited Speaker

  4. 14th Annual Meeting of International Society for Heart Research (Indian Section) Genomeet-2017 (2017) organized by CSIR-Institute of Genomics and Integrative Biology, New Delhi.

  5. International Conference on Reproductive Health with Emphasis on Occupational, Environmental and Life Style Factors and 26th Annual Meet of ISSRF (2016) organized by NIOH, Ahmedabad.

  6. National Conference on Reproductive Health Challenges: Issues and Remedies (2015) organized by ISSRF and IIS University, Jaipur. Invited Speaker

  7. National Conference on Emerging Issues in Environment, Occupational Health and Safety (2015) organized by ROHC-South, Bangalore.

  8. National Conference on Recent Advances in Chemical and Environmental Science: Emphasis on Occupational Health (2014) organized by ICMR (Govt. of India) and ITM University, Gwalior. Invited Speaker

  9. Biomaterials - 2014 International Conference (2014) organized by IIT-Delhi and Asian Polymer Association, New Delhi.

  10. International Conference on Stem Cells and Cancer (2013) organized by ICSCCB, Mumbai. Invited Speaker

  11. Materials in Medicine International Conference (2013) organized by CNR-Institute of Science and Technology for Ceramics at Faenza, Italy.

  12. International Conference on Environment and Occupational Health (2012) organized by Manipal University, Manipal.


Miscellaneous Information

Conference / Workshop Organized
  • ICMR, DHR, DST, DBT sponsored three days International Conference on Reproductive Health with Emphasis on Occupational, Environmental and Life Style Factors and 26th Annual Meet of ISSRF (2016) at NIOH (ICMR), Ahmedabad, India
  • ICMR, CSIR & INSA sponsored two days National Workshop on GLP (2013) at NIOH (ICMR), Ahmedabad, India (Org. Secretary)
Reviewer
  • Medical Science Monitor, Publisher: International Scientific Information Inc, USA
  • Biomarker Insights, Publisher: Libertas Academica, New Zealand
  • Reproductive Biology Insights, Publisher: Libertas Academica, New Zealand
  • Current Molecular Imaging, Bentham Science Publishers, USA
  • Biochemistry Insights, Publisher: Libertas Academica, New Zealand
  • Biomedical Materials, Publisher: IOP Science, UK
Members
  • CPCSEA (MoEF, Govt. of India) main nominee of several research institute/university/ pharmaceutical Co.
  • Editorial Board Member, Annals of Cytology and Pathology (former Peertechz Journal of Cytology and Pathology), Peertechz Publications Private Ltd., India.
  • Advisory Board Member, ICAR, NESA & DRDO sponsored National Conference on Food Security Issues & Environmental Challenges for Indian Agriculture in the Next Decades- 2016, Punjub University, Chandigarh.
  • Executive Committee Member (elected since 2013), Physiological Society of India.  
Research Guidance
  • Ph.D. Guide (Life Science, Gujarat University)
  • M.Sc. Project dissertation (Gujarat University, MSU-Udaipur, Ahmedabad University)