Name of Department

Neurobehavioral Toxicology Division

Objective

  • Research & Development in the areas of workers’ health exposure to environmental, chemicals, dust at time of work in respect of Neurobehavioral Toxicology.

Functions of the Department

  • To evaluate in respect of neurobehavioral consequences of exposure to environmental chemicals in laboratory animals as well as human.

Details of Scientific & Technical staff

Name

Designation 

Email 

Scientist 'F'
kashyap{AT}icmr{DOT}org{DOT}in;
rekhasadhu{AT}yahoo{DOT}co{DOT}in
Dr. Rajnish Gupta
TA
 
Mrs. M. V. Shrimali
MTS

Laboratory Facilities & Instruments

  1. Eight arm redial maze- for learning of spatial memory.
  2. Rota Rod - for screening chemicals/drugs affecting motor incoordination and neuro-toxicity
  3. Passive-Active avoidance system - for testing of compound on conditioned response (avoidance behavior )
  4. Grip Strength Meter- for assessing neuromuscular function /performance.
  5. Startel reflex Monitoring system - which assessing startle reflex is a key indicator in evaluating sensory and CNS performance.
  6. Water Maze - for assessing learning and spatial memory function / performance.
  7. Animal Activity monitoring system - for testing of compound on spontaneous motor activity.
  8. Cooks apparatus- for conditioning.
  9. Aggressive meter -Aggressive Behavior
  10. Hebbs Williams apparatus- for learning & memory.

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On going Proejcts

  • Experimental studies on endosulphan with special references to endocrine & reproductive dysfunction in rats.
    • Neurobehavioral Study
  • Experimental studies of arsenic with special references to endocrine & reproductive dysfunction in rats.
    • Neurobehavioral Study

Future Programmes

  • Research in my laboratory focuses on behavioral testing considered the alterations in nervous system that may identified; using neurobehavioral tests to evaluate neurobehavioral consequences of exposure to environmental chemicals in laboratory rats and mice. functional observation battery and forced behaviors tests (learning & memory) for use in this endeavor by using certain test apparatus/instruments such as rotarod, active and passive avoidance system, aggresometer, water maze monitoring setup, mazes, sterotoxic instrument, grip strength meter, startle reflex monitor and auto track animal activity monitor.

Project Completed

  1. Pharmacology and Toxicology of Industrial solvents:
    • Pyridine
    • Formaldehyde
    • Carbon Disulphide
  2. Neurobehavioral Toxicology of Metals:
    • Lead
    • Cadmium
    • Zinc
    • Manganese
    • Selenium

Publications and Research Reports

 

Miscellaneous Information

  • From this department, papers have been published in national and international proceedings and journals (over 300 papers and communications) as well established reputation in India and abroad

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